Medicinal chemists prepare and/or select appropriate compounds for biological evaluation that, if found to be active, could serve as LEAD COMPOUNDS. They then evaluate the STRUCTURE–ACTIVITY RELATIONSHIPS (SARs) of analogous compounds with regard to their in vitro and in vivo Read More …
Category: Learning Material
Structure-Based Drug Design (SBDD) : Positive Approach For Drug Discovery
Structure-based drug design is one of several methods in the rational drug design toolbox. Drug targets are typically key molecules involved in a specific metabolic or cell signaling pathway that is known, or believed, to be related to a particular Read More …
Aromatase (CYP19), a cytochrome P450 play an important role in breast tumour promotion
Estrogens play an important role in breast cancer development. Aromatase (CYP19), a cytochrome P450, is the enzyme that synthesizes estrogens. Through cell culture studies, it has been seen that in situ produced estrogen plays a more important role than circulating Read More …
